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Embryo-mediated genome editing for accelerated genetic improvement of livestock
Zachariah MCLEAN, Björn OBACK, Götz LAIBLE
《农业科学与工程前沿(英文)》 2020年 第7卷 第2期 页码 148-160 doi: 10.15302/J-FASE-2019305
Selecting beneficial DNA variants is the main goal of animal breeding. However, this process is inherently inefficient because each animal only carries a fraction of all desirable variants. Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains. To realize rapid genetic gain, precise edits need to be introduced into genomically-selected embryos, which minimizes the genetic lag. However, embryo-mediated precision editing by homology-directed repair (HDR) mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos. This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos. It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism, enable multiplex editing and multiply rare elite genotypes. Such a breeding strategy would enable a more targeted, accelerated approach for livestock improvement that allows stacking of beneficial variants, even including novel traits from outside the breeding population, in the most recent elite genetic background, essentially within a single generation.
关键词: animal breeding cattle cloning CRISPR/Cas9 cytoplasmic injection embryo genome editing germline chimaeras HDR livestock improvement TALENs
Highlights for special issue on “Large Animal Stem Cells”
Jianyong HAN
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 1-2 doi: 10.15302/J-FASE-2019251
Comments on this special issue on “Wheat Genetics and Breeding”
Zhonghu HE, Xu LLU
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 309-309 doi: 10.15302/J-FASE-2019264
A brief review of genome editing technology for generating animal models
Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH
《农业科学与工程前沿(英文)》 2020年 第7卷 第2期 页码 123-128 doi: 10.15302/J-FASE-2019309
The recent development of genome editing technologies has given researchers unprecedented power to alter DNA sequences at chosen genomic loci, thereby generating various genetically edited animal models. This mini-review briefly summarizes the development of major genome editing tools, focusing on the application of these tools to generate animal models in multiple species.
Cryopreservation of farm animal gametes and embryos: recent updates and progress
Zhengyuan HUANG, Lei GAO, Yunpeng HOU, Shien ZHU, Xiangwei FU
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 42-53 doi: 10.15302/J-FASE-2018231
Cryopreservation has undergone tremendous advances and is widely used in animal production based on decades of study of cellular permeability, freezability and empirical generalization. Several improvement are particularly important: the cryopreservation protocol has been continuously refined over the years to achieve greater reproductive performance; cryoprotective agents are more effective and less toxic than previously; there has been significant innovation in advanced cryopreservation systems and carriers. Despite this, there are still problems that urgently require practical solutions, such as remedies for cryodamage and encouraging the use of frozen–thawed porcine sperm in pig production.
关键词: vitrification gametes embryo animal production cryoprotective agent freezability
Highlights of special issue on “Wheat Genetics and Breeding”
Zhonghu HE, Zhendong ZHAO, Shunhe CHENG
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 207-209 doi: 10.15302/J-FASE-2019263
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 305-318 doi: 10.15302/J-FASE-2017154
Qi Lin, Xin Xu, Lihua, Wang, Qian Chen, Jing Fang, Xiaodong Shen, Liping Lou, Guangming Tian
《环境科学与工程前沿(英文)》 2017年 第11卷 第3期 doi: 10.1007/s11783-017-0924-8
关键词: Animal manure Biochar Metals Molecular species Pyrolysis
Highlights of special issue on Animal Science
Jun REN
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 257-259 doi: 10.15302/J-FASE-2017165
Antimicrobial use in food animal production: situation analysis and contributing factors
Ziping WU
《农业科学与工程前沿(英文)》 2018年 第5卷 第3期 页码 301-311 doi: 10.15302/J-FASE-2018207
By measuring the quantity and ways in which antimicrobials are used, and reviewing different technical and socioeconomic factors influencing antimicrobial use at farm level, this study discusses the main knowledge gaps in antimicrobial use in food animal production and provides recommendations for future research and policy development. The review reveals that antimicrobial use in food animals exhibit strong regional and species differences, and there are still large information gaps concerning the current state of antimicrobial use. Factors associated with animal health (including antimicrobial resistance), animal health improvement, economic costs and benefits relevant to animal diseases, and potential technological alternatives or alternative systems all have an impact on antimicrobial use on the farm. There is a clear need to resolve the data gap by monitoring antimicrobial use and developing an analytical framework to better understand farmer behaviors under different technical, economic and environmental circumstances.
关键词: antimicrobial use drivers for antimicrobial use food animal production
Wheat research and breeding in the new era of a high-quality reference genome
Rudi APPELS
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 225-232 doi: 10.15302/J-FASE-2019265
The publications of the International Wheat Genome Sequencing Consortium (IWGSC) released in August 2018 are reviewed and placed into the context of developments arising from the availability of the high-quality wheat genome assembly.
关键词: assembly technology molecular markers polyploidy transcript networks wheat genome
Electrolyzed water and its application in animal houses
Weichao ZHENG,Li NI,Baoming LI
《农业科学与工程前沿(英文)》 2016年 第3卷 第3期 页码 195-205 doi: 10.15302/J-FASE-2016109
关键词: disinfection poultry and livestock slightly acidic electrolyzed water neutral electrolyzed water
Genetic study and molecular breeding for high phosphorus use efficiency in maize
null
《农业科学与工程前沿(英文)》 2019年 第6卷 第4期 页码 366-379 doi: 10.15302/J-FASE-2019278
Phosphorus is the second most important macronutrient after nitrogen and it has many vital functions in the life of plants. Most soils have a low available P content, which has become a key limiting factor for increasing crop production. Also, low P use efficiency (PUE) of crops in conjunction with excessive application of P fertilizers has resulted in serious environmental problems. Thus, dissecting the genetic architecture of crop PUE, mining related quantitative trait loci (QTL) and using molecular breeding methods to improve high PUE germplasm are of great significance and serve as an efficient approach for the development of sustainable agriculture. In this review, molecular and phenotypic characteristics of maize inbred lines with high PUE, related QTL and genes as well as low-P responses are summarized. Based on this, a breeding strategy applying genomic selection as the core, and integrating the existing genetic information and molecular breeding techniques is proposed for breeding high PUE maize inbred lines and hybrids.
关键词: maize phosphorus use efficiency quantitative trait loci genetic study molecular breeding genomic selection
陈松林,徐文腾,卢昇,胡炜,王德寿,胡晓丽,周茜,刘清华,赵紫霞,覃钦博,王师,刘洋,崔忠凯
《中国工程科学》 2023年 第25卷 第4期 页码 214-226 doi: 10.15302/J-SSCAE-2023.07.023
Animal stem cells: the engineering development front of 2018
Wenye YUAN, Jianxiang XU, Chenying LI, Lijuan SHI, Aidong YANG, Yan WANG, Lu XING, Shaozhong KANG
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 93-95 doi: 10.15302/J-FASE-2018250
标题 作者 时间 类型 操作
Embryo-mediated genome editing for accelerated genetic improvement of livestock
Zachariah MCLEAN, Björn OBACK, Götz LAIBLE
期刊论文
A brief review of genome editing technology for generating animal models
Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH
期刊论文
Cryopreservation of farm animal gametes and embryos: recent updates and progress
Zhengyuan HUANG, Lei GAO, Yunpeng HOU, Shien ZHU, Xiangwei FU
期刊论文
Highlights of special issue on “Wheat Genetics and Breeding”
Zhonghu HE, Zhendong ZHAO, Shunhe CHENG
期刊论文
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
期刊论文
The speciation, leachability and bioaccessibility of Cu and Zn in animal manure-derived biochar: effect
Qi Lin, Xin Xu, Lihua, Wang, Qian Chen, Jing Fang, Xiaodong Shen, Liping Lou, Guangming Tian
期刊论文
Antimicrobial use in food animal production: situation analysis and contributing factors
Ziping WU
期刊论文